COLUMBUS, Ohio (Sports Network) - Terrelle Pryor finished 20-of-26 for 224 yards and four touchdowns, and rushed for 104 yards and a score as No. 2 Ohio State ripped Eastern Michigan, 73-20, in the first-ever meeting between the schools at the Horseshoe.
Joe Bauserman and Jordan Hall also threw for a touchdown -- Hall's to Pryor on a 20-yard connection -- for the Buckeyes (4-0), who open their Big Ten slate next Saturday at Illinois.
Dane Sanzenbacher found the end zone four times -- tying a school record -- among his nine receptions for 108 yards, while Jaamal Berry, Dan Herron and Kenny Guiton all posted one score on the ground.
Alex Gillett was 13-of-22 for 200 yards, two touchdowns and two sacks for the Eagles (0-4), who look to pick up a win in their MAC opener against Ohio next Saturday.
Kinsman Thomas and Donald Scott each tallied three catches and scored once each, and Dwayne Priest posted a rushing TD in the crushing setback.
Ohio State's first drive of the game proved fruitful, as Pryor hit the end zone on a snaking 53-yard dash. It was 14-0 on the Buckeyes' next possession when Pryor connected with Sanzenbacher on a 31-yard score.
Devontae Payne was under center for the ensuing EMU drive but fumbled, where OSU's John Simon recovered on the Eagles' 32. Devin Barclay's 43-yard attempt was good to cap that brief drive.
Herron's seven-yard TD scamper closed out the first quarter at 24-0, but Priest hit the end zone from two yards out for EMU's initial score early in the second.
Sanzenbacher added a nine-yard catch for a score for a 31-7 game, then posted a seven-yard TD reception which pushed Ohio State's lead to 31 points. Eastern Michigan closed out the half down 38-14 after Gillett hit Thomas for a 13-yard score.
Pryor hit Sanzenbacher for eight yards to cap the Buckeyes' opening drive of the second half, and the Eagles responded on a 32-yard connection from Gillett to Scott before the extra point was blocked.
Hall's trick-play completion to Pryor for a 20-yard touchdown pushed OSU to a 52-20 with under three minutes to go in the third.
The starters were rested in the fourth quarter, but the scoring didn't cease as Hall caught a 17-yard TD pass from Bauserman. Berry unleashed a 67-yard TD run and OSU was up 66-20 then Guiton's 15-yard rushing touchdown mercifully capped the scoring.